Resveratrol, trans-resveratrol (trans-3,5,4’-trihydroxystilbene) is a natural phytoalexin found in many different plants, especially grapes. (3, 4, 5). Phytoalexins are secondary structures that develop in plants against UV rays, damage and infections.
Resveratrol is found in high concentrations in plants, especially in red grapes, peanuts and pineapples. Resveratrol is a substance produced by black grapes to protect itself from factors such as cold weather conditions and fungal infections.
The first detection of resveratrol began when scientists evaluated the “French paradox” as the “French paradox” of the French cuisine, especially in the Bordeaux region, where heart disease was almost non-existent, despite the extremely high saturated fat, cholesterol-containing diet and heavy smoking. Results have been obtained that the antioxidant substance called resveratrol, which is formed on the skin of the "cabernet sauvignon" grapes grown in the humid air of the Bordeaux region, has a protective role against heart diseases, even when high-calorie and high-fat foods are consumed. David A. Sinclair from Harvard University Medical School described this discovery as "a discovery that has been awaited for 100 thousand years."
Resveratrol
The powerful antioxidant properties of resveratrol found in grape skins are 50 times more than vitamin E and 30 times more than vitamin C.
Like all other phenolic compounds, it is thought to have antioxidant activity. In this way, reactive oxygen species are cleaned, DNA damage is prevented and lipid peroxidation in the cell membrane is prevented.
It is effective in anti-aging; it is thought to have a slowing effect on aging and even extending life expectancy. It achieves this effect by increasing insulin sensitivity, increasing the enzymatic activity of the sirtuin gene, and also increasing the number of mitochondria and antioxidant effects.
It suppresses tissue damage and cellular proliferation with its anti-inflammatory effect. It protects skin structure.
It has been determined that it suppresses lipoprotein production and secretion from the liver. It has been determined that it lowers blood fats. In liver cell culture studies, it has also been determined that red grapes increase hepatic LDL receptor activity and HMG-CoA reductase activity.
It is thought that the anti-atherogenic (atherosclerosis prevention) effect may be due to increased metabolic rate, antioxidant activity, and decreased lipid peroxidation.
It helps regulate body weight.
Vascular tone regulator and anti-platelet effects of resveratrol, a polyphenol, have been determined.
With these effects, resveratrol is effective in the regulation of high body weight, cardiovascular, cerebrovascular disease, diabetes and cancer-related processes.